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Penile Injection Therapy Backgrounder - Penile injection therapy was discovered fortuitously. In 1980, the French physician Ronald Virag reported that during penile surgery, he inadvertently injected an anesthetized patient in the wrong part of the penis with papaverine - a substance derived from the opium poppy. The resulting relaxation of the smooth muscle of the penile arterial walls created an unexpected two-hour erection. This mistake prompted serious research into the use of injectable medications to relieve ED. Around the same time, Giles Brindley, a British physiologist and research scientist, discovered that injecting the drug phenoxybenzamine into the corpora cavernosa of the penis could produce an erection within minutes. At a meeting in Paris in 1984, New York urologist Dr. Adrian Zorgniotti presented his first case studies of self-injection utilizing a combination of papaverine and phentolamine. The latter drug blocks the action of neurotransmitters that cause vasoconstriction, causing the smooth muscles of the penis to relax. Two years later, Japanese researchers presented evidence that injecting the drug prostaglandin E-1 produced powerful erections. Slowly, news of the favorable results with the injectable medication began to spread within the small international community of urologists who were treating ED. Most began utilizing all three (papaverine, phentolamine, and prostaglandin E-1) in what was referred to as "trimix."
Alprostadil is a drug that has been available for the treatment for ED years before Viagra® was even a twinkle in the eyes of the pharmacologists at Pfizer. Yet alprostadil has all but disappeared as a front line treatment for ED, this is despite the fact that some clinical trials indicate that alprostadil is as effective as Viagra®! So why would that be?
One variation of the vacuum device involves a semirigid rubber sheath that is placed on the penis and remains there after erection is attained and during intercourse.
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To cash in on this huge and relatively new market, (at least in terms of its acceptance), it is no surprise that numerous pharmaceutical companies are rushing to find new drugs and new methodology, to treat erectile dysfunction.
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Once you're past that hurdle, experts say do acknowledge the problem exists and open the lines of communication about it.
Besides diabetes, which is very common in the U.S. today, there are other, somewhat rarer things that affect the nervous system and can in turn cause erectile dysfunction.
"There's the question of how you restore that needed blood supply," Sharlip said. "You may be able to restore the natural spongy tissue of these erection chambers, but in a patient with severe corporal fibrosis you also have to get the blood supply to come back into the new, restored tissue." Without that steady source of oxygen, any implant might meet the same fate as the tissue it had replaced, he said.
Zinc – Take 30 mg daily.
Because there are a variety of causes for ED, there are several different tests your doctor may use to diagnose the condition and determine its cause. Only after the cause of ED is determined can it be effectively treated.
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Erectile dysfunction. A vasodilator such as prostaglandin E1 can be injected into one of the corpora cavernosa. If the blood vessels are capable of dilating, a strong erection should develop within 5 minutes. A tourniquet may be used if a venous leak is present that would produce difficulty in maintaining an erection.
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